STUDY OF PSYCHOACTIVE ACTIVITY POTASSIUM SALT 5-(O-AMINOPHENYL)-1,3,4- OXADIAZOLE-2-THION (D-361)

Authors

  • S.Z. Rashidov Junior scientific Researcher at the S.Y. Yunusov Institute of Plant Chemistry of the Academy of Sciences of the Republic of Uzbekistan
  • S.D. Rakhimboev Basic doctoral student of the Institute of Plant Chemistry named after S.Yu. Yunusov of the Academy of Sciences of the Republic of Uzbekistan
  • Z.I. Sanoev PhD, Senior scientific Researcher at the S.Yu. Yunusov Institute of Plant Chemistry of the Academy of Sciences of the Republic of Uzbekistan
  • I.T. Abdinazarov Basic doctoral student of the Institute of Plant Chemistry named after S.Yu. Yunusov of the Academy of Sciences of the Republic of Uzbekistan
  • T.T. Khamroev Basic doctoral student of the Institute of Plant Chemistry named after S.Yu. Yunusov of the Academy of Sciences of the Republic of Uzbekistan
  • D.S. Ismailova PhD, Senior scientific Researcher at the S.Yu. Yunusov Institute of Plant Chemistry of the Academy of Sciences of the Republic of Uzbekistan
  • B.J.Elmuradov Ds Doctor of Chemical Sciences, professor at the S.Yu. Yunusov Institute of Plant Chemistry of the Academy of Sciences of the Republic of Uzbekistan

Keywords:

Potassium salt 5-(o-aminophenyl)-1,3,4-oxadiazol-2-thione, haloperidol, psychostimulant

Abstract

These papers present a study of the synthetic compound potassium salt 5-(o-aminophenyl)-1,3,4-oxadiazol-2-thione (D-361) at doses of 10; 30 and 60 mg/kg by oral administration on motor activity, locomotor action of phenamine, haloperidol catalepsy and M-cholinergic receptors in experimental animals. Based on the results of the experiment, it was found that psychostimulating, partially dopamine-blocking, M-cholinergic blocking action.

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Published

2022-09-24