Course of Autoimmune Thyroiditis During Pregnancy
Keywords:
Autoimmune thyroiditis, anti-thyroid peroxidase antibodies (AT-TPO), hypothyroidismAbstract
In recent years, the study of thyroid function during pregnancy, including the level of thyroid antibodies (anti-thyroglobulin antibodies, AT-TG) throughout pregnancy and their impact on pregnancy outcomes, has been the focus of endocrinologists, obstetricians-gynecologists, and pediatricians. In particular, hypothyroidism plays a key role in thyroid dysfunction and affects fetal development. This article examines the changes that may occur during pregnancy in patients with autoimmune thyroiditis.
References
Allan W.C, Haddow J.E, Palomaki G.E, Williams J.R, Mitchell M.L, Hermos R.J, et al. Maternal thyroid deficiency and pregnancy complications: implications for population screening. J Med Screen. 2000.7(3):127-30.
Abalovich M, Gutierrez S, Alcaraz G, Maccallini G, Garcia A, Levalle O.Overt and subclinical hypothyroidism complicating pregnancy.Thyroid. 2002 J.12 (1):63-8.
Bernal J. Thyroid hormone receptors in brain development and function. Nat Clin Pract 4. Endocrinol Metabol 2007;3:3:249
Blumenthal NJ, Byth K, Eastman CJ. Prevalence of thyroid dysfunction and thyroid antibodies in a private obstetrical practice in Sydney. Aust N Z J Obstet Gynaecol. 2016 Jun. 56 (3):307-11.
Glinoer D. Regulation of thyroid function in pregnancy: pathways of endocrine adaptation from physiology to pathology. Endocr Rev (1997) 18:404– 33.10.1210/edrv.18.3.0300
Glinoer D.,Riahi M., Griien J.P., Kinthaert J.//Ibid.- 1994. Vol. 79. -P.197-204. 7. 18:404 Klein R.Z., Haddow J.E., Faix J.D.et al.//clin.Endocri nol-1991.–vol.35.-P41-46.
Klein R.Z., Haddow J.E., Faix J.D.et al.//clin.Endocri nol-1991.–vol.35.-P41-46.
Kamijo k., Saito T., Sato M. et al Endoccrinol. Jap.-1990–Vol.37,N3.– P 397-403.
Leung AS, Millar LK, Koonings PP, Montoro M, Mestman JH. Perinatal outcome in hypothyroid pregnancies. Obstet Gynecol. 1993 Mar. 81 (3):349-53. McLeod DS, Cooper DS. The incidence and prevalence of thyroid autoimmunity. Endocrine 2012;42:252-65.
Porterfield S.P., Hendrich C.E.// Endicr. Rev. -1993 . – vol.14 – P.94-106.
Strango-Green A., Roman S.H., Cobin R .H. et al.//J.A.M.A-1990-Vol.264,N11.-P1422 1425
Vanderpump MP. The epidemiology of thyroid disease. Br Med Bull 2011;99:39-51.
Wilson KL, Casey BM, McIntire DD, Halvorson LM, Cunningham FG. Subclinical thyroid disease and the incidence of hypertension in pregnancy. Obstet Gynecol. 2012 Feb. 119 (2 Pt 1):315-20.
Stagnaro-Green A.Abalovich M.Alexander E.et al. Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and postpartum. Thyroid. 2011; 21: 1081-1125.
Krassas G.E. Poppe K.Glinoer D.Thyroid function and human reproductive health. Endocr Rev. 2010; 31: 702-755
Mannisto T.Mendola P.Grewal J.Xie Y.Chen Z.Laughon S.K.Thyroid diseases and adverse pregnancy outcomes in a contemporary US cohort.J Clin Endocrinol Metab. 2013; 98: 2725-2733
Bucci I, Giuliani C, Napolitano G. Thyroid-Stimulating Hormone Receptor Antibodies in Pregnancy: Clinical Relevance. Front Endocrinol (Lausanne). 2017 Jun 30;8:137. doi: 10.3389/fendo.2017.00137.
Alexander EK ,Pearce EN ,Brent G et al. Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and the postpartum. Thyroid. 2017; 27: 315-389
Barbesino G, Tomer Y. Clinical review: Clinical utility of TSH receptor antibodies. Clin Endocrinol Metab. 2013 Jun;98(6):2247-55. doi: 10.1210/jc.2012-4309.
Glinoer D ,Riahi M ,Grün JP ,Kinthaert J. Risk of subclinical hypothyroidism in pregnant women with asymptomatic autoimmune thyroid disorders. J Clin Endocrinol Metab. 1994; 79: 197-204.
Pearce EN, Oken E, Gillman MW, Lee SL, Magnani B, Platek D, Braverman LE. Association of first-trimester thyroid function test values with thyroperoxidase antibody status, smoking, and multivitamin use. Endocr Pract. 2008 Jan-Feb;14(1):33-9. doi:10.4158/EP.14.1.33.
Moreno-Reyes R ,Glinoer D ,Van Oyen H ,Vandevijvere S. High prevalence of thyroid disorders in pregnant women in a mildly iodine-deficient country: a population-based study. J Clin Endocrinol Metab. 2013; 98: 3694-3701
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