The Role Of Pancreatic Trypsin Inhibitor (Spink1) Gene Polymorphisms In The Course Of Acute Pancreatitis In The Uzbek Population

Authors

  • Madatov Kurbonboy Aminboyevich Department of Surgical Diseases, Tashkent State Medical University, Uzbekistan
  • Ismailov Uktam Safayevich Department of Surgical Diseases, Tashkent State Medical University, Uzbekistan
  • Sharopov Asliddin Nasriddinovich Department of Surgical Diseases, Tashkent State Medical University, Uzbekistan
  • Matmuratov Seyilkhon Kuronboyevich Department of Surgical Diseases, Tashkent State Medical University, Uzbekistan
  • Rakhimov Rasulbek Ibrokhimovich Department of Surgical Diseases, Tashkent State Medical University, Uzbekistan

Keywords:

Acute pancreatitis, pancreatic trypsin inhibitor (SPINK1), gene polymorphism

Abstract

This article examines the results of the influence of the SPINK1 (Asn34Ser) polymorphism on the incidence of acute pancreatitis. Environmental factors, in conjunction with genetic factors, play a crucial role in the mechanism of acute pancreatitis development. It was found that there are ethnic differences in the distribution of allele and genotype frequencies of this gene's polymorphic variant. Further development of molecular genetic research through studying the genetic basis of pancreatitis is important for developing new methods of diagnosis and determining treatment strategies with an individualized approach to each patient.

References

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Published

2026-02-21

Issue

Vol. 7 No. 02 (2026): Volume 07 Issue 02

Section

Articles

License

Copyright (c) 2026 Madatov Kurbonboy Aminboyevich, Ismailov Uktam Safayevich, Sharopov Asliddin Nasriddinovich, Matmuratov Seyilkhon Kuronboyevich, Rakhimov Rasulbek Ibrokhimovich

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