Predictive Approaches And Therapeutic Optimization In Odontogenic Inflammatory Diseases With Systemic Complications

Abstract

Odontogenic inflammatory diseases (OIDs) represent a major cause of emergency admissions and are often complicated by deep fascial infections and systemic involvement. Progression to systemic inflammatory response syndrome (SIRS), sepsis, and multiple organ dysfunction (MOD) poses significant threats to patient outcomes. This study synthesizes prognostic indicators, biomarkers, and optimized therapeutic strategies based on an analysis of 91 clinical cases and the development of a predictive digital algorithm. Emphasis is placed on cytokine predictors, systemic infection markers, microbiological dynamics, and differentiated therapy including G-CSF Filgrastim. The findings demonstrate substantial improvements in early detection, prevention of MOD, and overall treatment outcomes.